PTTG1

Securin is a protein that in humans is encoded by the PTTG1 gene.^[5][6][7]

PTTG1
Identifiers
Aliases	PTTG1, EAP1, HPTTG, PTTG, TUTR1, pituitary tumor-transforming 1, PTTG1 regulator of sister chromatid separation, securin, ECRAR
External IDs	OMIM: 604147; MGI: 1353578; HomoloGene: 3110; GeneCards: PTTG1; OMA:PTTG1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 160,421,855 bp[1] End 160,428,739 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.1 Start 43,311,077 bp[2] End 43,317,078 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone left testis ganglionic eminence right testis sperm gingival epithelium trabecular bone bone marrow mucosa of esophagus Top expressed in ciliary body secondary oocyte zygote retinal pigment epithelium primary oocyte iris blood primitive streak ankle otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity cysteine-type endopeptidase inhibitor activity DNA-binding transcription factor activity SH3 domain binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus cytosol Biological process chromosome segregation chromosome organization homologous chromosome segregation cellular response to DNA damage stimulus cell division spermatogenesis cell cycle anaphase-promoting complex-dependent catabolic process DNA repair regulation of transcription, DNA-templated negative regulation of peptidase activity negative regulation of endopeptidase activity regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of mitotic sister chromatid separation ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9232 30939 Ensembl ENSG00000164611 ENSMUSG00000020415 UniProt O95997 Q6IAL9 Q9CQJ7 RefSeq (mRNA) NM_004219 NM_001282382 NM_001282383 NM_001131054 NM_013917 NM_001362799 RefSeq (protein) NP_001269311 NP_001269312 NP_004210 NP_001269311.1 NP_001269312.1 NP_004210.1 NP_001124526 NP_038945 NP_001349728 Location (UCSC) Chr 5: 160.42 – 160.43 Mb Chr 11: 43.31 – 43.32 Mb PubMed search [3] [4]
Wikidata
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Function

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.^[7]

Interactions

PTTG1 has been shown to interact with:

• DNAJA1,^[8]
• Ku70^[9]
• P53,^[10]
• PTTG1IP,^[11] and
• RPS10.^[8]

Regulation

During Mitosis CDK1 phosphorylate PTTG1 at Ser-165.^[12] PTTG1 is down-regulated in melanoma cells in response to the cyclin-dependent kinase inhibitor PHA-848125.^[13]