DNAJB1

DnaJ homolog subfamily B member 1 is a protein that in humans is encoded by the DNAJB1 gene.^[5][6][7]

DNAJB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HDJ, 2QLD, 3AGX, 3AGY, 3AGZ, 4WB7
Identifiers
Aliases	DNAJB1, HSPF1, Hdj1, Hsp40, RSPH16B, Sis1, DnaJ heat shock protein family (Hsp40) member B1
External IDs	OMIM: 604572; MGI: 1931874; HomoloGene: 55957; GeneCards: DNAJB1; OMA:DNAJB1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 14,514,769 bp[1] End 14,560,391 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C2 Start 84,334,822 bp[2] End 84,339,282 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder mucosa of pharynx left testis ventricular zone right testis trachea buccal mucosa cell epithelium of esophagus vagina cardia Top expressed in seminiferous tubule motor neuron utricle primitive streak ascending aorta aortic valve fossa Epithelium of choroid plexus conjunctival fornix spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding ATPase binding Hsp70 protein binding chaperone binding protein binding ATPase activator activity transcription corepressor activity cadherin binding Cellular component cytosol nucleolus extracellular exosome nucleus nucleoplasm cytoplasm postsynaptic density soma dendritic spine sperm head postsynapse glutamatergic synapse Biological process regulation of cellular response to heat response to unfolded protein positive regulation of ATP-dependent activity protein folding chaperone cofactor-dependent protein refolding negative regulation of inclusion body assembly negative regulation of transcription from RNA polymerase II promoter in response to stress negative regulation of transcription by RNA polymerase II forebrain development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3337 81489 Ensembl ENSG00000132002 ENSMUSG00000005483 UniProt P25685 Q9QYJ3 RefSeq (mRNA) NM_001313964 NM_001300914 NM_006145 NM_018808 NM_001308227 RefSeq (protein) NP_001287843 NP_001300893 NP_006136 NP_001295156 NP_061278 Location (UCSC) Chr 19: 14.51 – 14.56 Mb Chr 8: 84.33 – 84.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

A fusion protein of DNAJB1 and PRKACA drives fibrolamellar hepatocellular carcinoma, a type of rare liver cancer.^[8]

Interactions

DNAJB1 has been shown to interact with:

• HSPA4,^[9] and
• STUB1^[10]