HSPA4

Heat shock 70 kDa protein 4 is a protein that in humans is encoded by the HSPA4 gene.^[5][6]

HSPA4
Identifiers
Aliases	HSPA4, APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY, heat shock protein family A (Hsp70) member 4
External IDs	OMIM: 601113; MGI: 1342292; HomoloGene: 1624; GeneCards: HSPA4; OMA:HSPA4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 133,052,013 bp[1] End 133,106,449 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 31.91 cM Start 53,150,641 bp[2] End 53,191,284 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad gingival epithelium islet of Langerhans right testis left testis mucosa of pharynx stromal cell of endometrium amniotic fluid tendon of biceps brachii tonsil Top expressed in otic placode saccule tail of embryo genital tubercle otic vesicle primitive streak epiblast Ileal epithelium trigeminal ganglion endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding ATP binding Cellular component cytoplasm cytosol extracellular exosome nucleus Biological process response to unfolded protein protein insertion into mitochondrial outer membrane chaperone-mediated protein complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3308 15525 Ensembl ENSG00000170606 ENSMUSG00000020361 UniProt P34932 Q61316 Q3U2G2 RefSeq (mRNA) NM_198431 NM_002154 NM_008300 RefSeq (protein) NP_002145 NP_032326 Location (UCSC) Chr 5: 133.05 – 133.11 Mb Chr 11: 53.15 – 53.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene was originally suggested to be a member of the heat shock protein 70 family.^[5] However it is now known that human HSPA4 is an equivalent to mouse the Apg-2 protein and is a member of the Hsp110 family.^[7]

Interactions

HSPA4 has been shown to interact with:

• APAF1^[8]
• DNAJB1,^[9]
• HDAC1,^[10]
• HSF1,^[11][12]
• HSPBP1,^[9]
• Histone deacetylase 2,^[10]
• NAD(P)H dehydrogenase (quinone 1),^[13]
• STUB1,^[14] and
• TTC1.^[9]