DOC2A

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

DOC2A

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.[5][6][7]

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DOC2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDOC2A, Doc2, double C2 domain alpha
External IDsOMIM: 604567; MGI: 109446; HomoloGene: 2657; GeneCards: DOC2A; OMA:DOC2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282062
NM_001282063
NM_001282068
NM_003586

NM_010069
NM_001368355
NM_001368356
NM_001368357
NM_001368358

RefSeq (protein)

NP_001268991
NP_001268992
NP_001268997
NP_003577

NP_034199
NP_001355284
NP_001355285
NP_001355286
NP_001355287

Location (UCSC)Chr 16: 30.01 – 30.02 MbChr 7: 126.45 – 126.45 Mb
PubMed search[3][4]
Wikidata
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There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.[7]

Interactions

DOC2A has been shown to interact with UNC13B[6][8] and UNC13A.[9]

References

Further reading

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