UNC13B

Protein unc-13 homolog B is a protein that in humans is encoded by the UNC13B gene.^[5][6]

UNC13B
Identifiers
Aliases	UNC13B, MUNC13, UNC13, Unc13h2, unc-13 homolog B (C. elegans), unc-13 homolog B, munc13-2
External IDs	OMIM: 605836; MGI: 1342278; HomoloGene: 31376; GeneCards: UNC13B; OMA:UNC13B - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 35,161,992 bp[1] End 35,405,338 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 43,058,953 bp[2] End 43,264,871 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung pancreatic ductal cell lower lobe of lung retinal pigment epithelium sperm upper lobe of lung upper lobe of left lung palpebral conjunctiva seminal vesicula epithelium of esophagus Top expressed in submandibular gland neural layer of retina lacrimal gland saccule epithelium of lens pineal gland secondary oocyte lobe of prostate parotid gland zygote More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding protein binding calmodulin binding diacylglycerol binding GTP-dependent protein binding calcium ion binding phospholipid binding syntaxin-1 binding Cellular component cytosol neuromuscular junction plasma membrane synapse cell junction cytoplasm Golgi apparatus membrane early phagosome terminal bouton calyx of Held presynaptic active zone ribbon synapse presynapse hippocampal mossy fiber to CA3 synapse glutamatergic synapse synaptic vesicle membrane presynaptic membrane presynaptic active zone cytoplasmic component Biological process exocytosis intracellular signal transduction synaptic vesicle docking positive regulation of synaptic vesicle priming synaptic transmission, glutamatergic regulation of short-term neuronal synaptic plasticity positive regulation of inhibitory postsynaptic potential neuromuscular junction development synaptic vesicle priming innervation chemical synaptic transmission synaptic vesicle exocytosis negative regulation of synaptic plasticity positive regulation of apoptotic process positive regulation of protein secretion cellular response to glucose stimulus phagosome maturation positive regulation of defense response to bacterium presynaptic dense core vesicle exocytosis synaptic vesicle maturation dense core granule priming neurotransmitter secretion glutamate secretion acrosomal vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10497 22249 Ensembl ENSG00000198722 ENSMUSG00000028456 UniProt O14795 Q9Z1N9 RefSeq (mRNA) NM_006377 NM_001330653 NM_001371186 NM_001371187 NM_001371188 NM_001371189 NM_001387551 NM_001387553 NM_001387554 NM_001387555 NM_001081413 NM_021468 NM_001310758 RefSeq (protein) NP_001317582 NP_006368 NP_001358115 NP_001358116 NP_001358117 NP_001358118 NP_001074882 NP_001297687 NP_067443 NP_001371035 Location (UCSC) Chr 9: 35.16 – 35.41 Mb Chr 4: 43.06 – 43.26 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.^[6]

Interactions

UNC13B has been shown to interact with:

• DOC2A,^[7][8]
• RIMS1,^[9][10]
• SPTBN2,^[11]
• STX1A,^[12] and
• STX1B.^[12]