DR1 (gene)

The DR1 gene is a gene in humans that codes for the Dr1 protein.^[5][6][7]

DR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JFI
Identifiers
Aliases	DR1, NC2, NC2-BETA, NC2B, down-regulator of transcription 1, NCB2
External IDs	OMIM: 601482; MGI: 1100515; HomoloGene: 38809; GeneCards: DR1; OMA:DR1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.1 Start 93,345,907 bp[1] End 93,369,493 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 52.82 cM Start 108,416,763 bp[2] End 108,428,392 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus human penis Skeletal muscle tissue of biceps brachii amniotic fluid buccal mucosa cell Skeletal muscle tissue of rectus abdominis skin of thigh tibia body of tongue oral cavity Top expressed in spermatocyte Gonadal ridge barrel cortex seminiferous tubule Paneth cell migratory enteric neural crest cell submandibular gland primitive streak atrioventricular valve hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function TBP-class protein binding DNA binding transcription factor binding protein binding transcription corepressor activity protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription coactivator activity RNA polymerase II general transcription initiation factor activity Cellular component nucleus negative cofactor 2 complex Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II histone H3 acetylation transcription, DNA-templated chromatin remodeling regulation of RNA polymerase II transcription preinitiation complex assembly positive regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1810 13486 Ensembl ENSG00000117505 ENSMUSG00000029265 UniProt Q01658 Q91WV0 RefSeq (mRNA) NM_001938 NM_026106 RefSeq (protein) NP_001929 NP_080382 Location (UCSC) Chr 1: 93.35 – 93.37 Mb Chr 5: 108.42 – 108.43 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.^[7]

Interactions

DR1 (gene) has been shown to interact with DRAP1.^[8][9]