DRAP1

Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene.^[5][6]

DRAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JFI
Identifiers
Aliases	DRAP1, NC2-alpha, DR1 associated protein 1
External IDs	OMIM: 602289; MGI: 1913806; HomoloGene: 4703; GeneCards: DRAP1; OMA:DRAP1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,919,274 bp[1] End 65,921,563 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,472,833 bp[2] End 5,475,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis granulocyte right hemisphere of cerebellum right frontal lobe left lobe of thyroid gland right lobe of thyroid gland apex of heart prefrontal cortex C1 segment Top expressed in muscle of thigh triceps brachii muscle dentate gyrus of hippocampal formation granule cell medial head of gastrocnemius muscle yolk sac sternocleidomastoid muscle neural layer of retina superior frontal gyrus temporal muscle ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity protein binding DNA-binding transcription factor activity transcription corepressor activity DNA binding identical protein binding DNA-binding transcription factor activity, RNA polymerase II-specific chromatin binding transcription coactivator activity transcription factor binding transcription coregulator activity Cellular component nucleus Biological process transcription, DNA-templated negative regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10589 66556 Ensembl ENSG00000175550 ENSMUSG00000024914 UniProt Q14919 Q9D6N5 RefSeq (mRNA) NM_006442 NM_001291080 NM_024176 RefSeq (protein) NP_006433 NP_001278009 NP_077138 Location (UCSC) Chr 11: 65.92 – 65.92 Mb Chr 19: 5.47 – 5.48 Mb PubMed search [3] [4]
Wikidata
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Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.^[6]

Interactions

DRAP1 has been shown to interact with FOXH1^[7] and DR1.^[8][9]