DUSP16

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.^[5][6][7][8]

DUSP16
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2VSW, 3TG3, 4YR8
Identifiers
Aliases	DUSP16, MKP-7, MKP7, dual specificity phosphatase 16
External IDs	OMIM: 607175; MGI: 1917936; HomoloGene: 15604; GeneCards: DUSP16; OMA:DUSP16 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 12,473,282 bp[1] End 12,562,863 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G1|6 65.77 cM Start 134,692,431 bp[2] End 134,769,588 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum ventricular zone tonsil right adrenal cortex left adrenal gland left adrenal cortex liver islet of Langerhans duodenum epithelium of colon Top expressed in saccule transitional epithelium of urinary bladder otic placode otic vesicle conjunctival fornix vestibular membrane of cochlear duct lacrimal gland right lung lobe epidermis hair follicle More reference expression data BioGPS n/a
Gene ontology Molecular function protein tyrosine phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity phosphatase activity Cellular component cytoplasm cytosol cytoplasmic vesicle nucleus nucleoplasm Biological process MAPK export from nucleus protein dephosphorylation peptidyl-tyrosine dephosphorylation MAPK phosphatase export from nucleus, leptomycin B sensitive negative regulation of MAPK cascade dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80824 70686 Ensembl ENSG00000280962 ENSG00000111266 ENSMUSG00000030203 UniProt Q9BY84 n/a RefSeq (mRNA) NM_030640 NM_001048054 NM_130447 NM_181320 RefSeq (protein) NP_085143 NP_085143.1 n/a Location (UCSC) Chr 12: 12.47 – 12.56 Mb Chr 6: 134.69 – 134.77 Mb PubMed search [3] [4]
Wikidata
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The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM]^[8]

Interactions

DUSP16 has been shown to interact with MAPK14^[9][10] and MAPK8IP1.^[11]