MAPK8IP1

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.^[5][6]

MAPK8IP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2G01, 2GMX, 2H96, 3OXI, 3PTG, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4E73, 4G1W, 4H39, 4HYS, 4HYU, 4IZY
Identifiers
Aliases	MAPK8IP1, IB1, JIP-1, JIP1, PRKM8IP, mitogen-activated protein kinase 8 interacting protein 1
External IDs	OMIM: 604641; MGI: 1309464; HomoloGene: 31314; GeneCards: MAPK8IP1; OMA:MAPK8IP1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 45,885,651 bp[1] End 45,906,465 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 92,214,021 bp[2] End 92,231,608 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment right frontal lobe anterior pituitary right hemisphere of cerebellum tibial nerve anterior cingulate cortex prefrontal cortex ventricular zone Brodmann area 9 Brodmann area 10 Top expressed in superior frontal gyrus primary visual cortex entorhinal cortex perirhinal cortex cerebellar cortex dentate gyrus of hippocampal formation granule cell superior surface of tongue gallbladder dorsomedial hypothalamic nucleus central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MAP-kinase scaffold activity protein kinase inhibitor activity protein binding kinesin binding protein kinase binding JUN kinase binding mitogen-activated protein kinase kinase binding mitogen-activated protein kinase kinase kinase binding Cellular component cytoplasm cell body cytosol dendritic growth cone endoplasmic reticulum membrane mitochondrial membranes membrane dentate gyrus mossy fiber axonal growth cone synapse axon dendrite endoplasmic reticulum mitochondrion perinuclear region of cytoplasm neuron projection nucleus plasma membrane Biological process regulation of transcription, DNA-templated negative regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic process negative regulation of JNK cascade regulation of JNK cascade JUN phosphorylation negative regulation of JUN kinase activity vesicle-mediated transport signal transduction positive regulation of MAPK cascade positive regulation of JNK cascade regulation of CD8-positive, alpha-beta T cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9479 19099 Ensembl ENSG00000121653 ENSMUSG00000027223 UniProt Q9UQF2 Q9WVI9 RefSeq (mRNA) NM_005456 NM_001202445 NM_001202446 NM_011162 RefSeq (protein) NP_005447 NP_001189374 NP_001189375 NP_035292 Location (UCSC) Chr 11: 45.89 – 45.91 Mb Chr 2: 92.21 – 92.23 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.^[7]

Interactions

MAPK8IP1 has been shown to interact with MAP3K10,^[8] DUSP16,^[9] Mitogen-activated protein kinase 9,^[8][10] MAPK8,^[10][11] LRP2,^[12][13] LRP1,^[12] MAP3K12,^[8] MAP2K7,^[8] MAPK8IP2^[8] and MAP3K11.^[8]