DUSP6

Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene.^[5][6][7]

DUSP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HZM, 1MKP
Identifiers
Aliases	DUSP6, HH19, MKP3, PYST1, dual specificity phosphatase 6
External IDs	OMIM: 602748; MGI: 1914853; HomoloGene: 55621; GeneCards: DUSP6; OMA:DUSP6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.33 Start 89,347,235 bp[1] End 89,352,501 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D1 Start 99,099,093 bp[2] End 99,103,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland pericardium monocyte lactiferous duct visceral pleura lower lobe of lung retinal pigment epithelium granulocyte parietal pleura trachea Top expressed in granulocyte left lung lobe stroma of bone marrow maxillary prominence retinal pigment epithelium parotid gland endocardial cushion tail of embryo atrioventricular valve right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity hydrolase activity MAP kinase tyrosine/serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity Cellular component nucleoplasm cytosol cytoplasm Biological process negative regulation of protein phosphorylation cell differentiation positive regulation of cell death response to organic cyclic compound regulation of fibroblast growth factor receptor signaling pathway protein dephosphorylation response to organic substance MAPK cascade response to nitrosative stress positive regulation of apoptotic process negative regulation of ERK1 and ERK2 cascade peptidyl-tyrosine dephosphorylation response to growth factor dorsal/ventral pattern formation regulation of endodermal cell fate specification dephosphorylation regulation of heart growth Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1848 67603 Ensembl ENSG00000139318 ENSMUSG00000019960 UniProt Q16828 Q9DBB1 RefSeq (mRNA) NM_022652 NM_001946 NM_026268 RefSeq (protein) NP_001937 NP_073143 NP_080544 Location (UCSC) Chr 12: 89.35 – 89.35 Mb Chr 10: 99.1 – 99.1 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas and, unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.^[5] Upregulation of MKP-3 has been shown to alleviate chronic postoperative pain.^[8][9]

Interactions

DUSP6 has been shown to interact with MAPK3.^[10]