DUSP7

Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene.^[5][6][7]

DUSP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Y2E
Identifiers
Aliases	DUSP7, MKPX, PYST2, dual specificity phosphatase 7
External IDs	OMIM: 602749; MGI: 2387100; HomoloGene: 1468; GeneCards: DUSP7; OMA:DUSP7 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.2 Start 52,048,919 bp[1] End 52,056,571 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 106,245,831 bp[2] End 106,252,923 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte gingival epithelium human penis nipple skin of thigh mucosa of pharynx vulva secondary oocyte cervix epithelium skin of abdomen Top expressed in zygote secondary oocyte genital tubercle primary oocyte tail of embryo lip lacrimal gland neural layer of retina visual cortex primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein binding MAP kinase tyrosine/serine/threonine phosphatase activity hydrolase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity Cellular component cytoplasm cytosol nucleoplasm Biological process protein dephosphorylation MAPK cascade negative regulation of MAP kinase activity peptidyl-tyrosine dephosphorylation dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1849 235584 Ensembl ENSG00000164086 ENSMUSG00000053716 UniProt Q16829 Q91Z46 RefSeq (mRNA) NM_001947 NM_153459 RefSeq (protein) NP_001938 NP_703189 Location (UCSC) Chr 3: 52.05 – 52.06 Mb Chr 9: 106.25 – 106.25 Mb PubMed search [3] [4]
Wikidata
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Function

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to de-phosphorylate both tyrosine (EC 3.1.3.48) and serine / threonine (EC 3.1.3.16) residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses.^[7][8]

It is known to bind and dephosphorylate ErkII, and as it, along with the other members of the DUSP family expresses high selectively for MAP kinases, it has been suggested that it functions as a method for selectively activating/deactivating different members of that family.^[9]