E2F3

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.^[5]

E2F3
Identifiers
Aliases	E2F3, E2F-3, E2F transcription factor 3
External IDs	OMIM: 600427; MGI: 1096340; HomoloGene: 74413; GeneCards: E2F3; OMA:E2F3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.3 Start 20,401,879 bp[1] End 20,493,714 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.2 Start 30,090,558 bp[2] End 30,170,046 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Brodmann area 23 middle temporal gyrus endothelial cell tendon of biceps brachii gingival epithelium tibia cartilage tissue visceral pleura bone marrow Top expressed in primitive streak mandibular prominence maxillary prominence cumulus cell medullary collecting duct abdominal wall atrium tail of embryo hair follicle genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding protein dimerization activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific transcription factor binding Cellular component nucleus transcription regulator complex RNA polymerase II transcription regulator complex nucleoplasm Biological process positive regulation of transcription, DNA-templated negative regulation of fat cell proliferation cell cycle transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of cell population proliferation positive regulation of transcription by RNA polymerase II positive regulation of vascular associated smooth muscle cell apoptotic process negative regulation of transcription by RNA polymerase II regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1871 13557 Ensembl ENSG00000112242 ENSMUSG00000016477 UniProt O00716 O35261 RefSeq (mRNA) NM_001243076 NM_001949 NM_001289920 NM_010093 NM_001359994 RefSeq (protein) NP_001230005 NP_001940 NP_001276849 NP_034223 NP_001346923 Location (UCSC) Chr 6: 20.4 – 20.49 Mb Chr 13: 30.09 – 30.17 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.^[6]

Interactions

E2F3 has been shown to interact with TFE3,^[7] IGF2.^[8] and RYBP.^[9]

See also

• E2F