EEF1B2

Elongation factor 1-beta is a protein that in humans is encoded by the EEF1B2 gene.^[5][6]

EEF1B2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B64
Identifiers
Aliases	EEF1B2, EEF1B, EEF1B1, EF1B, eukaryotic translation elongation factor 1 beta 2
External IDs	OMIM: 600655; MGI: 1929520; HomoloGene: 1480; GeneCards: EEF1B2; OMA:EEF1B2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.3 Start 206,159,585 bp[1] End 206,162,928 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C2 Start 63,215,984 bp[2] End 63,219,645 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas Achilles tendon left ovary lymph node skin of abdomen islet of Langerhans right ovary epithelium of colon canal of the cervix granulocyte Top expressed in epiblast ovary genital tubercle thymus ventricular zone pancreas uterus spleen bone marrow placenta More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding translation elongation factor activity guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol endoplasmic reticulum nucleus eukaryotic translation elongation factor 1 complex Biological process translational elongation protein biosynthesis response to ethanol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1933 55949 Ensembl ENSG00000114942 ENSG00000283391 ENSMUSG00000025967 UniProt P24534 O70251 RefSeq (mRNA) NM_021121 NM_001037663 NM_001959 NM_018796 RefSeq (protein) NP_001032752 NP_001950 NP_066944 NP_061266 Location (UCSC) Chr 2: 206.16 – 206.16 Mb Chr 1: 63.22 – 63.22 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR.^[6]

Interactions

EEF1B2 has been shown to interact with EEF1G^[7][8] and HARS.^[9]