EHD1

EH domain-containing protein 1, also known as testilin or PAST homolog 1 (PAST1), is a protein that in humans is encoded by the EHD1 gene^[5] belonging to the EHD protein family.

EHD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JQ6, 2KFF, 2KFG, 2KFH, 2KSP
Identifiers
Aliases	EHD1, H-PAST, HPAST1, PAST, PAST1, EH domain containing 1
External IDs	OMIM: 605888; MGI: 1341878; HomoloGene: 81678; GeneCards: EHD1; OMA:EHD1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,851,642 bp[1] End 64,888,296 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 4.4 cM Start 6,326,755 bp[2] End 6,350,126 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis granulocyte blood spleen appendix apex of heart right coronary artery lymph node right hemisphere of cerebellum Top expressed in granulocyte testicle white adipose tissue yolk sac placenta spermatid jejunum human kidney circulatory system heart More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calcium ion binding GTP binding metal ion binding protein binding ATP binding cadherin binding identical protein binding Cellular component endosome cell projection early endosome membrane membrane lipid droplet plasma membrane cilium recycling endosome membrane platelet dense tubular network membrane ciliary membrane ciliary pocket membrane endosome membrane extracellular exosome Biological process cellular response to nerve growth factor stimulus endocytosis low-density lipoprotein particle clearance positive regulation of cholesterol storage blood coagulation positive regulation of myoblast fusion cell projection organization protein localization to cilium positive regulation of endocytic recycling cholesterol homeostasis intracellular protein transport protein homooligomerization neuron projection development protein transport endocytic recycling cilium assembly transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10938 13660 Ensembl ENSG00000110047 ENSMUSG00000024772 UniProt Q9H4M9 Q9WVK4 RefSeq (mRNA) NM_001282444 NM_001282445 NM_006795 NM_010119 RefSeq (protein) NP_001269373 NP_001269374 NP_006786 NP_034249 Location (UCSC) Chr 11: 64.85 – 64.89 Mb Chr 19: 6.33 – 6.35 Mb PubMed search [3] [4]
Wikidata
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Function

This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors.^[5]

Interactions

EHD1 has been shown to interact with Insulin-like growth factor 1 receptor^[6] and SNAP29.^[6]