SNAP29

Synaptosomal-associated protein 29 is a protein that in humans is encoded by the SNAP29 gene.^[5][6][7]

SNAP29
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WY4
Identifiers
Aliases	SNAP29, CEDNIK, SNAP-29, synaptosome associated protein 29kDa, synaptosome associated protein 29
External IDs	OMIM: 604202; MGI: 1914724; HomoloGene: 3512; GeneCards: SNAP29; OMA:SNAP29 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 20,859,007 bp[1] End 20,891,214 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 17,223,850 bp[2] End 17,248,691 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis gonad buccal mucosa cell monocyte tendon of biceps brachii islet of Langerhans gastrocnemius muscle stromal cell of endometrium liver Top expressed in zygote spermatocyte secondary oocyte muscle of thigh gastrula spermatid granulocyte esophagus yolk sac blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity protein binding syntaxin binding Cellular component cytoplasm centrosome Golgi apparatus cell projection membrane plasma membrane cilium autophagosome membrane SNARE complex ciliary membrane ciliary pocket membrane cytoplasmic vesicle presynapse Golgi membrane nucleoplasm autophagosome cytosol azurophil granule membrane synapse Biological process vesicle targeting synaptic vesicle fusion to presynaptic active zone membrane membrane fusion autophagy autophagosome maturation cell projection organization synaptic vesicle priming protein transport exocytosis autophagosome membrane docking neutrophil degranulation cilium assembly vesicle fusion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9342 67474 Ensembl ENSG00000099940 ENSMUSG00000022765 UniProt O95721 Q9ERB0 RefSeq (mRNA) NM_004782 NM_023348 RefSeq (protein) NP_004773 NP_075837 Location (UCSC) Chr 22: 20.86 – 20.89 Mb Chr 16: 17.22 – 17.25 Mb PubMed search [3] [4]
Wikidata
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Function

This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene.^[7]

Interactions

SNAP29 has been shown to interact with Syntaxin 3^[5] and EHD1.^[8]

SNAP29 was shown to interact with CVB3 and EV-D68 viral protease 3C.^[9][10]

See also

• CEDNIK Syndrome