EIF2B1

Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene.^[5]

EIF2B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ECS
Identifiers
Aliases	EIF2B1, EIF2B, EIF2BA, eukaryotic translation initiation factor 2B subunit alpha, EIF2Balpha
External IDs	OMIM: 606686; MGI: 2384802; HomoloGene: 1080; GeneCards: EIF2B1; OMA:EIF2B1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 123,620,406 bp[1] End 123,633,766 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 63.67 cM Start 124,708,276 bp[2] End 124,717,194 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte monocyte Achilles tendon body of uterus skin of hip skin of thigh right coronary artery granulocyte tibial arteries Top expressed in zygote secondary oocyte morula morula primary oocyte yolk sac primitive streak embryo epiblast blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor activity guanyl-nucleotide exchange factor activity protein binding identical protein binding Cellular component cytoplasm cytosol membrane plasma membrane eukaryotic translation initiation factor 2B complex Biological process response to peptide hormone response to heat response to glucose cell metabolism oligodendrocyte development protein biosynthesis translational initiation T cell receptor signaling pathway regulation of translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1967 209354 Ensembl ENSG00000111361 ENSMUSG00000029388 UniProt Q14232 Q99LC8 RefSeq (mRNA) NM_001414 NM_145371 RefSeq (protein) NP_001405 NP_663346 Location (UCSC) Chr 12: 123.62 – 123.63 Mb Chr 5: 124.71 – 124.72 Mb PubMed search [3] [4]
Wikidata
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Interactions

EIF2B1 has been shown to interact with EIF2B5.^[6][7]