EIF2B5

Translation initiation factor eIF-2B subunit epsilon is a protein that in humans is encoded by the EIF2B5 gene.^[5][6]

EIF2B5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JUI
Identifiers
Aliases	EIF2B5, CACH, CLE, EIF-2B, EIF2Bepsilon, LVWM, eukaryotic translation initiation factor 2B subunit epsilon
External IDs	OMIM: 603945; MGI: 2446176; HomoloGene: 2903; GeneCards: EIF2B5; OMA:EIF2B5 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,135,038 bp[1] End 184,146,127 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 20,317,567 bp[2] End 20,328,073 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve tendon of biceps brachii gastrocnemius muscle anterior pituitary right hemisphere of cerebellum middle temporal gyrus minor salivary glands mucosa of transverse colon granulocyte right lobe of thyroid gland Top expressed in spermatocyte epiblast morula morula lacrimal gland muscle of thigh spermatid ventricular zone tail of embryo blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor activity guanyl-nucleotide exchange factor activity protein binding translation initiation factor binding Cellular component cytoplasm eukaryotic translation initiation factor 2B complex nucleus cytosol Biological process astrocyte development ageing response to peptide hormone response to heat response to glucose response to endoplasmic reticulum stress astrocyte differentiation ovarian follicle development myelination oligodendrocyte development positive regulation of translational initiation hippocampus development translational initiation response to lithium ion protein biosynthesis positive regulation of apoptotic process positive regulation of translation T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8893 224045 Ensembl ENSG00000145191 ENSMUSG00000003235 UniProt Q13144 Q8CHW4 RefSeq (mRNA) NM_003907 NM_172265 RefSeq (protein) NP_003898 NP_758469 Location (UCSC) Chr 3: 184.14 – 184.15 Mb Chr 16: 20.32 – 20.33 Mb PubMed search [3] [4]
Wikidata
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Interactions

EIF2B5 has been shown to interact with EIF2B2^[7] and EIF2B1.^[7][8]