EIF2B2

Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.^[5][6]

EIF2B2
Identifiers
Aliases	EIF2B2, EIF-2Bbeta, EIF2B, eukaryotic translation initiation factor 2B subunit beta, EIF2Bbeta
External IDs	OMIM: 606454; MGI: 2145118; HomoloGene: 6507; GeneCards: EIF2B2; OMA:EIF2B2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 75,002,921 bp[1] End 75,012,366 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D1 Start 85,266,255 bp[2] End 85,273,402 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lobe of thyroid gland right lobe of thyroid gland right adrenal cortex gastrocnemius muscle left adrenal gland muscle of thigh left adrenal cortex popliteal artery tibial arteries mucosa of transverse colon Top expressed in condyle fossa renal corpuscle internal carotid artery external carotid artery endocardial cushion saccule yolk sac substantia nigra medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor activity guanyl-nucleotide exchange factor activity GTP binding protein binding ATP binding Cellular component cytoplasm cytosol eukaryotic translation initiation factor 2B complex Biological process response to peptide hormone response to heat response to glucose central nervous system development cell metabolism ovarian follicle development myelination oligodendrocyte development regulation of translational initiation protein biosynthesis translational initiation T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8892 217715 Ensembl ENSG00000119718 ENSMUSG00000004788 UniProt P49770 Q99LD9 RefSeq (mRNA) NM_014239 NM_145445 RefSeq (protein) NP_055054 NP_663420 Location (UCSC) Chr 14: 75 – 75.01 Mb Chr 12: 85.27 – 85.27 Mb PubMed search [3] [4]
Wikidata
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Function

Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1; MIM 606686), beta (EIF2B2), gamma (EIF2B3; MIM 606273), delta (EIF2B4; MIM 606687), and epsilon (EIF2B5; MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP.^[6]

Interactions

EIF2B2 has been shown to interact with EIF2B5^[7] and NCK1.^[8]