EIF2S2

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.^[5][6]

EIF2S2
Identifiers
Aliases	EIF2S2, EIF2, EIF2B, EIF2beta, PPP1R67, eIF-2-beta, eukaryotic translation initiation factor 2 subunit beta
External IDs	OMIM: 603908; MGI: 1914454; HomoloGene: 2904; GeneCards: EIF2S2; OMA:EIF2S2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 34,088,309 bp[1] End 34,112,243 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H1|2 76.89 cM Start 154,713,330 bp[2] End 154,734,855 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue oral cavity glutes right ventricle trabecular bone deltoid muscle muscle of arm biceps brachii mucosa of sigmoid colon triceps brachii muscle Top expressed in morula blastocyst yolk sac tail of embryo embryo genital tubercle muscle of thigh embryo spermatocyte ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation factor activity, RNA binding protein binding translation initiation factor activity metal ion binding RNA binding mRNA binding translation initiation factor binding Cellular component cytoplasm cytosol nucleus eukaryotic translation initiation factor 2 complex Biological process translational initiation male germ cell proliferation male gonad development in utero embryonic development transmembrane transport protein biosynthesis formation of translation preinitiation complex formation of cytoplasmic translation initiation complex Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8894 67204 Ensembl ENSG00000125977 ENSMUSG00000074656 UniProt P20042 Q99L45 RefSeq (mRNA) NM_003908 NM_001316363 NM_001316364 NM_026030 RefSeq (protein) NP_001303292 NP_001303293 NP_003899 NP_080306 Location (UCSC) Chr 20: 34.09 – 34.11 Mb Chr 2: 154.71 – 154.73 Mb PubMed search [3] [4]
Wikidata
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Function

Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β, this article), and gamma (γ), with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the eIF2 complex for another round of initiation.^[6]

Regulation

Both eIF2α and eIF2β expression is regulated by the NRF1 transcription factor.^[7]

See also

• eIF2