EIF2S3

Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.^[5][6][7]

EIF2S3
Identifiers
Aliases	EIF2S3, EIF2, EIF2G, EIF2gamma, eIF-2gA, eukaryotic translation initiation factor 2 subunit gamma, MRXSBRK, MEHMO
External IDs	OMIM: 300161; MGI: 1349431; HomoloGene: 90888; GeneCards: EIF2S3; OMA:EIF2S3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.11 Start 24,054,946 bp[1] End 24,078,810 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X C3|X 41.52 cM Start 93,232,313 bp[2] End 93,256,468 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium parietal pleura skin of arm visceral pleura tibia mucosa of ileum monocyte epithelium of nasopharynx palpebral conjunctiva epithelium of colon Top expressed in molar maxillary prominence genital tubercle mandibular prominence hand epiblast foot ventricular zone medial ganglionic eminence atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding translation factor activity, RNA binding protein binding translation initiation factor activity GTPase activity cadherin binding Cellular component cytoplasm cytosol extracellular exosome nucleus eukaryotic translation initiation factor 2 complex Biological process translational initiation transmembrane transport protein biosynthesis formation of translation preinitiation complex Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1968 26905 Ensembl ENSG00000130741 ENSMUSG00000035150 UniProt P41091 Q9Z0N1 RefSeq (mRNA) NM_001415 NM_012010 RefSeq (protein) NP_001406 NP_036140 Location (UCSC) Chr X: 24.05 – 24.08 Mb Chr X: 93.23 – 93.26 Mb PubMed search [3] [4]
Wikidata
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Function

Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β), and gamma (γ, this article), with the protein encoded by this gene representing the gamma subunit.^[7]

See also

• eIF2