EIF3B

Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene.^[5][6]

EIF3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KRB, 2NLW, 5K1H
Identifiers
Aliases	EIF3B, EIF3-ETA, EIF3-P110, EIF3-P116, EIF3S9, PRT1, eukaryotic translation initiation factor 3 subunit B
External IDs	OMIM: 603917; MGI: 106478; HomoloGene: 2780; GeneCards: EIF3B; OMA:EIF3B - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.3 Start 2,354,086 bp[1] End 2,380,745 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 78.97 cM Start 140,405,083 bp[2] End 140,429,115 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas skin of abdomen skin of leg muscle layer of sigmoid colon stromal cell of endometrium left uterine tube gastrocnemius muscle ventricular zone right ovary smooth muscle tissue Top expressed in epiblast spermatid ventricular zone yolk sac lip otic vesicle lactiferous gland somite morula morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular adaptor activity translation initiation factor binding protein binding translation initiation factor activity nucleic acid binding RNA binding Cellular component cytosol eukaryotic translation initiation factor 3 complex eukaryotic translation initiation factor 3 complex, eIF3m extracellular exosome cytoplasm eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex synapse Biological process translational initiation IRES-dependent viral translational initiation protein biosynthesis viral translational termination-reinitiation regulation of translational initiation formation of cytoplasmic translation initiation complex cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8662 27979 Ensembl ENSG00000106263 ENSMUSG00000056076 UniProt P55884 Q8JZQ9 RefSeq (mRNA) NM_001037283 NM_003751 NM_001362791 NM_001362792 NM_001362793 NM_182712 NM_133916 RefSeq (protein) NP_001032360 NP_003742 NP_001349720 NP_001349721 NP_001349722 NP_598677 Location (UCSC) Chr 7: 2.35 – 2.38 Mb Chr 5: 140.41 – 140.43 Mb PubMed search [3] [4]
Wikidata
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Interactions

EIF3B has been shown to interact with P70-S6 Kinase 1^[7] and EIF3A.^{[5][8][9][10]}

See also

• Eukaryotic initiation factor 3 (eIF3)