EIF3A

Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene.^[5][6][7] It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.

EIF3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J8B, 3J8C
Identifiers
Aliases	EIF3A, EIF3, EIF3S10, P167, TIF32, eIF3-p170, eIF3-theta, p180, p185, eukaryotic translation initiation factor 3 subunit A
External IDs	OMIM: 602039; MGI: 95301; HomoloGene: 2779; GeneCards: EIF3A; OMA:EIF3A - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.11 Start 119,033,670 bp[1] End 119,080,823 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D3 Start 60,749,555 bp[2] End 60,779,096 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii tibia buccal mucosa cell amniotic fluid epithelium of nasopharynx gingival epithelium skin of thigh mucosa of paranasal sinus skin of hip glutes Top expressed in lacrimal gland tail of embryo maxillary prominence mandibular prominence otic placode human fetus saccule primitive streak hair follicle seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural molecule activity translation initiation factor activity receptor tyrosine kinase binding RNA binding mRNA binding Cellular component eukaryotic translation initiation factor 3 complex nucleolus nucleus membrane microtubule cytoplasm cytosol multi-eIF complex eukaryotic translation initiation factor 3 complex, eIF3e eukaryotic translation initiation factor 3 complex, eIF3m postsynaptic density eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex Biological process translational initiation formation of cytoplasmic translation initiation complex viral translational termination-reinitiation protein biosynthesis IRES-dependent viral translational initiation negative regulation of ERK1 and ERK2 cascade translation reinitiation cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8661 13669 Ensembl ENSG00000107581 ENSMUSG00000024991 UniProt Q14152 P23116 RefSeq (mRNA) NM_003750 NM_010123 RefSeq (protein) NP_003741 NP_034253 Location (UCSC) Chr 10: 119.03 – 119.08 Mb Chr 19: 60.75 – 60.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

EIF3A has been shown to interact with:

• DISC1,^[8]
• EIF3B,^{[9][10][11][12]}
• EIF3C,^[9][10]
• EIF3D,^[9][10][13]
• EIF3EIP,^[13][14]
• EIF3F,^[9][10][13]
• EIF3G,^[9][10]
• EIF3H,^[9][10][13]
• EIF3I^[9][13][15]
• EIF3J,^[9][10]
• EIF3K,^[9][13]
• EIF3S6,^[9][13][14]
• EIF4B,^[16]
• EIF4G2,^[17][18] and
• FBXO32.^[19]

See also

• Eukaryotic initiation factor 3 (eIF3)