EIF3F

Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a protein that in humans is encoded by the EIF3F gene.^[5][6]

EIF3F
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J8B, 3J8C
Identifiers
Aliases	EIF3F, EIF3S5, eIF3-p47, eukaryotic translation initiation factor 3 subunit F, MRT67
External IDs	OMIM: 603914; MGI: 1913335; HomoloGene: 2783; GeneCards: EIF3F; OMA:EIF3F - orthologs
EC number	3.4.19.12
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 7,970,251 bp[1] End 8,001,862 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 108,533,624 bp[2] End 108,542,158 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ganglionic eminence left ovary skin of leg skin of abdomen body of pancreas ventricular zone right ovary stromal cell of endometrium body of uterus Top expressed in Paneth cell transitional epithelium of urinary bladder vas deferens vestibular sensory epithelium medial ganglionic eminence hair follicle utricle endothelial cell of lymphatic vessel internal carotid artery fossa More reference expression data BioGPS n/a
Gene ontology Molecular function cysteine-type peptidase activity translation initiation factor activity thiol-dependent deubiquitinase peptidase activity protein binding hydrolase activity translation initiation factor binding Cellular component cytoplasm cytosol eukaryotic translation initiation factor 3 complex membrane eukaryotic translation initiation factor 3 complex, eIF3m eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex Biological process proteolysis translational initiation protein biosynthesis IRES-dependent viral translational initiation protein deubiquitination formation of cytoplasmic translation initiation complex cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8665 66085 Ensembl ENSG00000175390 ENSMUSG00000031029 UniProt O00303 Q9DCH4 RefSeq (mRNA) NM_003754 NM_025344 RefSeq (protein) NP_003745 NP_079620 Location (UCSC) Chr 11: 7.97 – 8 Mb Chr 7: 108.53 – 108.54 Mb PubMed search [3] [4]
Wikidata
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Interactions

EIF3F has been shown to interact with Mammalian target of rapamycin^[7] and EIF3A.^[8][9][10]

See also

• Eukaryotic initiation factor 3 (eIF3)