EIF3K

Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the EIF3K gene.^[5][6][7]

EIF3K
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RZ4, 3J8B, 3J8C
Identifiers
Aliases	EIF3K, EIF3-p28, EIF3S12, HSPC029, M9, MSTP001, PLAC-24, PLAC24, PRO1474, PTD001, ARG134, eukaryotic translation initiation factor 3 subunit K
External IDs	OMIM: 609596; MGI: 1921080; HomoloGene: 8292; GeneCards: EIF3K; OMA:EIF3K - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 38,619,082 bp[1] End 38,636,955 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 28,670,797 bp[2] End 28,681,289 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right auricle of heart granulocyte muscle of thigh mucosa of transverse colon muscle layer of sigmoid colon rectum body of stomach skin of abdomen monocyte Top expressed in maxillary prominence mandibular prominence epiblast molar embryo embryo fetal liver hematopoietic progenitor cell ventricular zone internal carotid artery otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribosome binding protein binding translation initiation factor activity RNA binding Cellular component eukaryotic translation initiation factor 3 complex extracellular exosome membrane nucleus cytoplasm cytosol eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex Biological process translational initiation regulation of translational initiation protein biosynthesis formation of cytoplasmic translation initiation complex cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27335 73830 Ensembl ENSG00000178982 ENSG00000282986 ENSMUSG00000053565 UniProt Q9UBQ5 Q9DBZ5 RefSeq (mRNA) NM_001300992 NM_001308393 NM_013234 NM_001285942 NM_001285943 NM_028659 RefSeq (protein) NP_001287921 NP_001295322 NP_037366 NP_001272871 NP_001272872 NP_082935 Location (UCSC) Chr 19: 38.62 – 38.64 Mb Chr 7: 28.67 – 28.68 Mb PubMed search [3] [4]
Wikidata
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Function

The ~800 kDa eukaryotic initiation factor 3 (eIF3) is the largest eIF and contains at least 12 subunits, including eIF3k/EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 43S preinitiation complex.^[8][7]

Interactions

eIF3k has been shown to interact with Cyclin D3^[9] and eIF3a.^[6][10]

See also

• Eukaryotic initiation factor 3 (eIF3)