EIF4B

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.^[5]

EIF4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WI8, 2J76
Identifiers
Aliases	EIF4B, EIF-4B, PRO1843, eukaryotic translation initiation factor 4B
External IDs	OMIM: 603928; MGI: 95304; HomoloGene: 83162; GeneCards: EIF4B; OMA:EIF4B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,006,282 bp[1] End 53,042,215 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F2 Start 101,982,208 bp[2] End 102,005,608 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence left ovary epithelium of colon islet of Langerhans stromal cell of endometrium body of pancreas right ovary ventricular zone monocyte Top expressed in tail of embryo lacrimal gland genital tubercle epiblast ankle ventricular zone somite mandibular prominence left lung lobe vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding ribosomal small subunit binding helicase activity RNA strand-exchange activity RNA strand annealing activity RNA binding translation initiation factor activity Cellular component cytosol eukaryotic translation initiation factor 4F complex polysome Biological process nuclear-transcribed mRNA poly(A) tail shortening regulation of translational initiation formation of translation preinitiation complex eukaryotic translation initiation factor 4F complex assembly protein biosynthesis translational initiation cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1975 75705 Ensembl ENSG00000063046 ENSMUSG00000058655 UniProt P23588 Q8BGD9 RefSeq (mRNA) NM_001300821 NM_001417 NM_018507 NM_001330654 NM_145625 RefSeq (protein) NP_001287750 NP_001317583 NP_001408 NP_663600 Location (UCSC) Chr 12: 53.01 – 53.04 Mb Chr 15: 101.98 – 102.01 Mb PubMed search [3] [4]
Wikidata
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Interactions

eIF4B has been shown to interact with and stimulate the activity of eIF4A and bind to the eIF3 complex through the eIF3A subunit.^[6] This interaction results in the recruitment of the eukaryotic small ribosomal subunit (40S) to the mRNA which will in turn set the stage for the later steps leading to elongation.

See also

• Eukaryotic translation
• eIF4F