Eukaryotic translation initiation factor 4 gamma 1

Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.^[5][6]

EIF4G1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LJ2, 1UG3, 2W97, 4AZA, 4F02
Identifiers
Aliases	EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18, Eukaryotic translation initiation factor 4 gamma, eukaryotic translation initiation factor 4 gamma 1
External IDs	OMIM: 600495; MGI: 2384784; HomoloGene: 110725; GeneCards: EIF4G1; OMA:EIF4G1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,314,495 bp[1] End 184,335,358 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 20,487,063 bp[2] End 20,511,634 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skin of leg skin of abdomen stromal cell of endometrium right lobe of liver muscle of thigh right lobe of thyroid gland anterior pituitary apex of heart right adrenal gland Top expressed in lacrimal gland tail of embryo primitive streak genital tubercle ventricular zone somite muscle of thigh hair follicle submandibular gland internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor activity protein binding RNA binding mRNA binding ATP binding translation factor activity, RNA binding eukaryotic initiation factor 4E binding translation initiation factor binding molecular adaptor activity cadherin binding identical protein binding Cellular component cytosol membrane nucleus cytoplasm polysome eukaryotic translation initiation factor 4F complex cytosolic small ribosomal subunit postsynapse Biological process nuclear-transcribed mRNA poly(A) tail shortening regulation of mRNA stability behavioral fear response positive regulation of neuron differentiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay viral process regulation of translation regulation of translational initiation cap-dependent translational initiation protein biosynthesis translational initiation mitochondrion organization positive regulation of cell population proliferation negative regulation of autophagy negative regulation of peptidyl-threonine phosphorylation positive regulation of cell growth positive regulation of protein metabolic process developmental process positive regulation of peptidyl-serine phosphorylation cellular macromolecule biosynthetic process regulation of gene silencing by miRNA regulation of cellular response to stress positive regulation of G1/S transition of mitotic cell cycle negative regulation of neuron death positive regulation of eukaryotic translation initiation factor 4F complex assembly regulation of presynapse assembly positive regulation of mRNA cap binding regulation of polysome binding positive regulation of cell death cellular response to nutrient levels energy homeostasis lung development response to ethanol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1981 208643 Ensembl ENSG00000114867 ENSMUSG00000045983 UniProt Q04637 Q6NZJ6 RefSeq (mRNA) NM_198244 NM_001194946 NM_001194947 NM_001291157 NM_004953 NM_182917 NM_198241 NM_198242 NM_001005331 NM_145941 NM_001304432 RefSeq (protein) NP_001181875 NP_001181876 NP_001278086 NP_004944 NP_886553 NP_937884 NP_937885 NP_937887 NP_001291361 NP_666053 NP_001390389 NP_001390390 NP_001390391 NP_001390392 NP_001390393 NP_001390394 NP_001390395 NP_001390396 NP_001390397 Location (UCSC) Chr 3: 184.31 – 184.34 Mb Chr 16: 20.49 – 20.51 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.^[7] eIF4G serves as a scaffold, interacting with mRNA and the other components of the eIF4F complex, as well as the PABP and eIF3.

Interactions

Eukaryotic translation initiation factor 4 gamma has been shown to interact with MKNK1,^[8] EIF4A1,^[9][10][11] EIF4E,^{[10][11][12][13][14]} MKNK2^[15] and PABPC1.^[16]

See also

• Eukaryotic initiation factor