EIF4G2

Eukaryotic translation initiation factor 4 gamma 2 (also called p97, NAT1, and DAP-5) is a protein that in humans is encoded by the EIF4G2 gene.^[5][6]

EIF4G2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D3M, 3L6A, 4IUL
Identifiers
Aliases	EIF4G2, AAG1, DAP5, NAT1, P97, eukaryotic translation initiation factor 4 gamma 2
External IDs	OMIM: 602325; MGI: 109207; HomoloGene: 37477; GeneCards: EIF4G2; OMA:EIF4G2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 10,797,050 bp[1] End 10,808,940 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 58.0 cM Start 110,666,957 bp[2] End 110,682,237 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura germinal epithelium parietal pleura gingival epithelium tibia ganglionic eminence epithelium of colon ventricular zone superficial temporal artery epithelium of nasopharynx Top expressed in tail of embryo renal corpuscle genital tubercle Gonadal ridge molar Rostral migratory stream conjunctival fornix retinal pigment epithelium ciliary body migratory enteric neural crest cell More reference expression data BioGPS n/a
Gene ontology Molecular function translation factor activity, RNA binding protein binding translation initiation factor activity RNA binding cadherin binding mRNA binding Cellular component cytosol eukaryotic translation initiation factor 4F complex membrane Biological process translational initiation cell death protein biosynthesis regulation of translation regulation of translational initiation negative regulation of autophagy positive regulation of cell growth cellular macromolecule biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1982 13690 Ensembl ENSG00000110321 ENSMUSG00000005610 UniProt P78344 Q62448 RefSeq (mRNA) NM_001418 NM_001042559 NM_001172705 NM_001040131 NM_013507 RefSeq (protein) NP_001036024 NP_001166176 NP_001409 NP_001035221 NP_038535 Location (UCSC) Chr 11: 10.8 – 10.81 Mb Chr 7: 110.67 – 110.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by the eIF4G2 gene shares similarity with the C-terminal region of eIF4G1 that contains the binding sites for eIF4A and eIF3. eIF4G2 additionally contains a binding site for eIF4E at the N-terminus. Unlike eIF4G1, which supports cap-dependent and independent translation, the eIF4G2 gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.^[7]

Interactions

EIF4G2 has been shown to interact with EIF3A.^[8][9]