EIF4G3

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene.^[5][6] The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template.^[7] Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.^[8]

EIF4G3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HU3
Identifiers
Aliases	EIF4G3, eIF-4G 3, eIF4G 3, eIF4GII, eukaryotic translation initiation factor 4 gamma 3
External IDs	OMIM: 603929; MGI: 1923935; HomoloGene: 2789; GeneCards: EIF4G3; OMA:EIF4G3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 20,806,292 bp[1] End 21,177,285 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 137,993,022 bp[2] End 138,208,508 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Epithelium of choroid plexus right testis left testis frontal pole Brodmann area 10 ventricular zone epithelium of colon lateral nuclear group of thalamus middle frontal gyrus Top expressed in muscle of thigh tail of embryo genital tubercle neural layer of retina seminiferous tubule knee joint cerebellar cortex primary visual cortex superior frontal gyrus triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA cap binding translation factor activity, RNA binding translation initiation factor activity RNA binding protein binding mRNA binding Cellular component cytosol eukaryotic translation initiation factor 4F complex Biological process translational initiation viral process protein biosynthesis regulation of translation regulation of translational initiation negative regulation of autophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8672 230861 Ensembl ENSG00000075151 ENSMUSG00000028760 UniProt O43432 Q80XI3 RefSeq (mRNA) NM_001198801 NM_001198802 NM_001198803 NM_003760 NM_001391892 NM_001391893 NM_001391894 NM_001391895 NM_001391896 NM_001391897 NM_001391898 NM_001391899 NM_001391900 NM_001391901 NM_001391902 NM_001391903 NM_001391904 NM_001391905 NM_001391906 NM_001391907 NM_001256195 NM_001256198 NM_172703 NM_001355699 NM_001355700 RefSeq (protein) NP_001185730 NP_001185731 NP_001185732 NP_003751 NP_001243124 NP_001243127 NP_766291 NP_001342628 NP_001342629 NP_001356059 NP_001356060 Location (UCSC) Chr 1: 20.81 – 21.18 Mb Chr 4: 137.99 – 138.21 Mb PubMed search [3] [4]
Wikidata
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Interactions

EIF4G3 has been shown to interact with PABPC1.^[9]