EMR3

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene.^[3][4] EMR3 is a member of the adhesion GPCR family.^[5][6] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[7]

ADGRE3
Identifiers
Aliases	ADGRE3, EMR3, adhesion G protein-coupled receptor E3
External IDs	OMIM: 606101; HomoloGene: 50009; GeneCards: ADGRE3; OMA:ADGRE3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 14,619,117 bp[1] End 14,690,027 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte granulocyte gonad appendix bone marrow bone marrow cells spleen right lung gallbladder n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane extracellular region membrane plasma membrane secretory granule membrane ficolin-1-rich granule membrane integral component of plasma membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction neutrophil degranulation adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84658 n/a Ensembl ENSG00000131355 n/a UniProt Q9BY15 n/a RefSeq (mRNA) NM_001289158 NM_001289159 NM_032571 NM_152939 n/a RefSeq (protein) NP_001276087 NP_001276088 NP_115960 n/a Location (UCSC) Chr 19: 14.62 – 14.69 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.^[8] Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.^[9] Mice, next to Emr2, lack the Emr3 gene.^[10]

Function

The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.^[11]

Ligands

A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.^[9]