ENAH (gene)

Protein enabled homolog is a protein that in humans is encoded by the ENAH gene.^[5][6]

ENAH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HO2, 2IYB, 2XQN, 4MY6
Identifiers
Aliases	ENAH, ENA, MENA, NDPP1, enabled homolog (Drosophila), actin regulator
External IDs	OMIM: 609061; MGI: 108360; HomoloGene: 134005; GeneCards: ENAH; OMA:ENAH - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.12 Start 225,486,835 bp[1] End 225,653,142 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H5|1 84.93 cM Start 181,723,949 bp[2] End 181,847,555 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein epithelium of colon secondary oocyte vena cava urethra seminal vesicula cardia ventricular zone Achilles tendon Skeletal muscle tissue of rectus abdominis Top expressed in vestibular membrane of cochlear duct Rostral migratory stream ascending aorta seminal vesicula stria vascularis vestibular sensory epithelium genital tubercle tail of embryo medullary collecting duct aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding WW domain binding actin binding protein binding profilin binding Cellular component filopodium cell junction plasma membrane cell projection synapse cytoskeleton focal adhesion lamellipodium cytoplasm cytosol Biological process axon guidance actin polymerization or depolymerization actin polymerization-dependent cell motility Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55740 13800 Ensembl ENSG00000154380 ENSMUSG00000022995 UniProt Q8N8S7 Q03173 RefSeq (mRNA) NM_001008493 NM_018212 NM_001083120 NM_001083121 NM_008680 NM_010135 RefSeq (protein) NP_001008493 NP_060682 NP_001364410 NP_001364411 NP_001364412 NP_001076589 NP_001076590 NP_032706 NP_034265 Location (UCSC) Chr 1: 225.49 – 225.65 Mb Chr 1: 181.72 – 181.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ENAH has been shown to interact with ABI1,^[7] ZYX,^[7][8] and PCARE.^[9]