EXOC7

Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene.^[5][6] It was formerly known as Exo70.

EXOC7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PFT
Identifiers
Aliases	EXOC7, 2-5-3p, EX070, EXO70, EXOC1, Exo70p, YJL085W, exocyst complex component 7, BLOM4, NEDSEBA
External IDs	OMIM: 608163; MGI: 1859270; HomoloGene: 41019; GeneCards: EXOC7; OMA:EXOC7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 76,081,016 bp[1] End 76,121,576 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 116,178,827 bp[2] End 116,198,059 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube ganglionic eminence parotid gland ventricular zone right lobe of thyroid gland stromal cell of endometrium external globus pallidus pituitary gland right hemisphere of cerebellum left lobe of thyroid gland Top expressed in triceps brachii muscle spermatocyte spermatid superior frontal gyrus ventricular zone muscle of thigh primary visual cortex temporal muscle neural layer of retina neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm cytosol plasma membrane growth cone membrane exocyst centriolar satellite membrane microtubule organizing center Flemming body Biological process protein transport regulation of entry of bacterium into host cell regulation of macroautophagy exocytosis transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23265 53413 Ensembl ENSG00000182473 ENSMUSG00000020792 UniProt Q9UPT5 O35250 RefSeq (mRNA) NM_001013839 NM_001145297 NM_001145298 NM_001145299 NM_001282313 NM_001282314 NM_015219 NM_001375974 NM_001375975 NM_001375976 NM_001162872 NM_016857 NM_001347636 NM_001362838 NM_001362839 NM_001378960 NM_001378961 RefSeq (protein) NP_001013861 NP_001138769 NP_001138770 NP_001138771 NP_001269242 NP_001269243 NP_056034 NP_001362903 NP_001362904 NP_001362905 NP_001156344 NP_001334565 NP_058553 NP_001349767 NP_001349768 NP_001365889 NP_001365890 Location (UCSC) Chr 17: 76.08 – 76.12 Mb Chr 11: 116.18 – 116.2 Mb PubMed search [3] [4]
Wikidata
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Exo70 exocyst complex subunit
crystal structure of the s. cerevisiae exocyst component exo70p
Identifiers
Symbol	Exo70
Pfam	PF03081
Pfam clan	CL0295
InterPro	IPR004140
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

It forms one subunit of the exocyst complex. First discovered in Saccharomyces cerevisiae, this and other exocyst proteins have been observed in several other eukaryotes, including humans.^[7] In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localised at the tip of the bud, the major site of exocytosis in yeast.^[7] It interacts with the Rho3 GTPase.^[8] This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud).^[9] In humans, the functions of this protein and the exocyst complex are less well characterised: this protein is expressed in several tissues and is thought to also be involved in exocytosis.^[10]

Interactions

EXOC7 has been shown to interact with EXOC4^[11][12] and RHOQ.^[12]