EXOC4

Exocyst complex component 4 is a protein that in humans is encoded by the EXOC4 gene.^[5][6][7]

EXOC4
Identifiers
Aliases	EXOC4, SEC8, SEC8L1, Sec8p, exocyst complex component 4
External IDs	OMIM: 608185; MGI: 1096376; HomoloGene: 40654; GeneCards: EXOC4; OMA:EXOC4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q33 Start 133,253,073 bp[1] End 134,066,589 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 A3.3|6 14.59 cM Start 33,226,020 bp[2] End 33,950,914 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells Achilles tendon epithelium of colon ventricular zone ganglionic eminence skin of arm deltoid muscle sural nerve tibialis anterior muscle Skeletal muscle tissue of rectus abdominis Top expressed in Rostral migratory stream fossa internal carotid artery Epithelium of choroid plexus external carotid artery condyle epithelium of lens calvaria substantia nigra lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein binding protein N-terminus binding Cellular component cytoplasm myelin sheath abaxonal region microvillus cytosol plasma membrane membrane exocyst growth cone membrane synapse cell projection Flemming body Biological process protein transport paraxial mesoderm formation regulation of macroautophagy vesicle docking involved in exocytosis protein targeting to membrane exocytosis Golgi to plasma membrane transport vesicle targeting chemical synaptic transmission transport vesicle tethering involved in exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60412 20336 Ensembl ENSG00000131558 ENSMUSG00000029763 UniProt Q96A65 O35382 RefSeq (mRNA) NM_001037126 NM_021807 NM_009148 NM_001347089 RefSeq (protein) NP_001032203 NP_068579 NP_001334018 NP_033174 Location (UCSC) Chr 7: 133.25 – 134.07 Mb Chr 6: 33.23 – 33.95 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[7]

Interactions

EXOC4 has been shown to interact with:

• DLG3,^[8]
• DLG4,^[8][9]
• EXOC3,^[6][8]
• EXOC7,^[6][8] and
• GRIN2B.^[8]