Exosome component 2

Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene.^[5][6]

EXOSC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC2, RRP4, Rrp4p, hRrp4p, p7, Exosome component 2, SHRF
External IDs	OMIM: 602238; MGI: 2385133; HomoloGene: 6095; GeneCards: EXOSC2; OMA:EXOSC2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.12 Start 130,693,721 bp[1] End 130,707,288 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 31,560,727 bp[2] End 31,571,361 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone gonad Achilles tendon cerebellar hemisphere left ovary granulocyte right hemisphere of cerebellum right ovary rectum Top expressed in embryo molar epiblast blastocyst yolk sac embryo morula somite ventricular zone neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3'-5'-exoribonuclease activity exoribonuclease activity 7S RNA binding protein binding RNA binding Cellular component cytoplasm cytosol exosome (RNase complex) nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) nucleus nucleoplasm nucleolus Biological process nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent rRNA catabolic process regulation of mRNA stability exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' CUT catabolic process positive regulation of cell growth exonucleolytic catabolism of deadenylated mRNA rRNA processing U4 snRNA 3'-end processing polyadenylation-dependent snoRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23404 227715 Ensembl ENSG00000130713 ENSMUSG00000039356 UniProt Q13868 Q8VBV3 RefSeq (mRNA) NM_001282708 NM_001282709 NM_014285 NM_144886 RefSeq (protein) NP_001269637 NP_001269638 NP_055100 NP_659135 Location (UCSC) Chr 9: 130.69 – 130.71 Mb Chr 2: 31.56 – 31.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Mammalian mRNAs contain AU-rich elements (AREs) within their three prime untranslated regions. In yeast, 3-prime-to-5-prime mRNA degradation is mediated by the exosome, a multisubunit particle. EXOSC2 (which is homologous to the yeast Rrp4 protein) is a component of the human exosome.^[7]

Interactions

Exosome component 2 has been shown to interact with:

• Exosome component 4,^[8] and
• Exosome component 7.^[8]