Exosome component 7

Exosome component 7, also known as EXOSC7, is a human gene, the protein product of which is part of the exosome complex.^[5]

EXOSC7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC7, EAP1, RRP42, Rrp42p, hRrp42p, p8, Exosome component 7
External IDs	OMIM: 606488; MGI: 1913696; HomoloGene: 8994; GeneCards: EXOSC7; OMA:EXOSC7 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 44,975,241 bp[1] End 45,036,066 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F4 Start 122,942,280 bp[2] End 122,965,194 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte thoracic diaphragm skin of leg right adrenal gland left adrenal gland skin of abdomen left adrenal cortex right adrenal cortex body of tongue Top expressed in otic placode morula saccule otic vesicle primitive streak embryo epiblast yolk sac somite blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3'-5'-exoribonuclease activity exoribonuclease activity protein binding RNA binding Cellular component cytoplasm cytosol exosome (RNase complex) nucleolus nucleoplasm nucleus nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) Biological process regulation of mRNA stability RNA catabolic process rRNA processing exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U1 snRNA 3'-end processing U4 snRNA 3'-end processing U5 snRNA 3'-end processing exonucleolytic catabolism of deadenylated mRNA nuclear mRNA surveillance nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent mRNA catabolic process rRNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23016 66446 Ensembl ENSG00000075914 ENSMUSG00000025785 UniProt Q15024 Q9D0M0 RefSeq (mRNA) NM_015004 NM_001081188 NM_025568 RefSeq (protein) NP_055819 NP_001074657 Location (UCSC) Chr 3: 44.98 – 45.04 Mb Chr 9: 122.94 – 122.97 Mb PubMed search [3] [4]
Wikidata
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Interactions

Exosome component 7 has been shown to interact with:

• Exosome component 1,^[6][7]
• Exosome component 2,^[6] and
• Exosome component 6.^[6]