Exosome component 8

Exosome component 8, also known as EXOSC8, is a human gene, the protein product of which is part of the exosome complex.^[5]

EXOSC8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC8, CIP3, EAP2, OIP2, RRP43, Rrp43p, bA421P11.3, p9, PCH1C, Exosome component 8
External IDs	OMIM: 606019; MGI: 1916889; HomoloGene: 12323; GeneCards: EXOSC8; OMA:EXOSC8 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q13.3 Start 36,998,816 bp[1] End 37,025,881 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 C Start 54,636,099 bp[2] End 54,642,814 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence right uterine tube gonad left ovary right ovary right testis left testis body of uterus canal of the cervix Top expressed in yolk sac tail of embryo genital tubercle blastocyst primitive streak morula medial ganglionic eminence endothelial cell of lymphatic vessel ventricular zone endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function exoribonuclease activity protein binding RNA binding identical protein binding mRNA 3'-UTR AU-rich region binding Cellular component cytoplasm cytosol exosome (RNase complex) nucleolus nucleus nucleoplasm nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) Biological process regulation of mRNA stability RNA processing RNA catabolic process rRNA processing exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U1 snRNA 3'-end processing U4 snRNA 3'-end processing U5 snRNA 3'-end processing exonucleolytic catabolism of deadenylated mRNA nuclear mRNA surveillance nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent mRNA catabolic process biological process rRNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11340 69639 Ensembl ENSG00000120699 ENSMUSG00000027752 UniProt Q96B26 Q9D753 RefSeq (mRNA) NM_181503 NM_001163570 NM_027148 RefSeq (protein) NP_852480 NP_001157042 NP_081424 Location (UCSC) Chr 13: 37 – 37.03 Mb Chr 3: 54.64 – 54.64 Mb PubMed search [3] [4]
Wikidata
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Interactions

Exosome component 8 has been shown to interact with:

• Exosome component 5^[6] and
• Exosome component 6.^[6]