Exosome component 6

Exosome complex exonuclease MTR3 is an enzyme that in humans is encoded by the EXOSC6 gene.^[5][6][7]

EXOSC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC6, EAP4, MTR3, Mtr3p, hMtr3p, p11, Exosome component 6
External IDs	OMIM: 606490; MGI: 1919794; HomoloGene: 12469; GeneCards: EXOSC6; OMA:EXOSC6 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 70,246,778 bp[1] End 70,251,940 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 111,782,971 bp[2] End 111,784,296 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell endothelial cell Brodmann area 23 postcentral gyrus Brodmann area 46 primary visual cortex superior frontal gyrus middle temporal gyrus Achilles tendon entorhinal cortex Top expressed in embryo embryo blastocyst morula vasculature vasculature of organ Temporal Lobe Amygdala spinal cord brain stem More reference expression data BioGPS n/a
Gene ontology Molecular function exoribonuclease activity RNA binding Cellular component cytoplasm cytosol exosome (RNase complex) nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) nucleolus nucleus nucleoplasm Biological process regulation of mRNA stability nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' rRNA 3'-end processing rRNA catabolic process DNA deamination nuclear mRNA surveillance exonucleolytic catabolism of deadenylated mRNA U4 snRNA 3'-end processing polyadenylation-dependent snoRNA 3'-end processing rRNA processing positive regulation of isotype switching isotype switching RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 118460 72544 Ensembl ENSG00000223496 ENSMUSG00000109941 UniProt Q5RKV6 Q8BTW3 RefSeq (mRNA) NM_058219 NM_028274 RefSeq (protein) NP_478126 NP_082550 Location (UCSC) Chr 16: 70.25 – 70.25 Mb Chr 8: 111.78 – 111.78 Mb PubMed search [3] [4]
Wikidata
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This gene product constitutes one of the subunits of the multisubunit particle called the exosome complex, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.^[7]

Interactions

Exosome component 6 has been shown to interact with Exosome component 7,^[6]Exosome component 8^[6] and Exosome component 1.^[6]