F11 receptor

Junctional adhesion molecule A is a protein that in humans is encoded by the F11R gene.^[5][6][7] It has also been designated as CD321 (cluster of differentiation 321).

F11R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NBQ, 3EOY, 3TSZ, 4ODB
Identifiers
Aliases	F11R, F11r, 9130004G24, AA638916, ESTM33, JAM, JAM-1, JAM-A, Jcam, Jcam1, Ly106, CD321, JAM1, JAMA, KAT, PAM-1, F11 receptor
External IDs	OMIM: 605721; MGI: 1321398; HomoloGene: 14255; GeneCards: F11R; OMA:F11R - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 160,995,211 bp[1] End 161,021,343 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.43 cM Start 171,265,103 bp[2] End 171,292,171 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa right lung rectum islet of Langerhans upper lobe of left lung mucosa of transverse colon minor salivary glands gallbladder skin of abdomen left lobe of thyroid gland Top expressed in saccule otic placode corneal stroma left lung lobe otic vesicle lactiferous gland choroid plexus of fourth ventricle transitional epithelium of urinary bladder epithelium of stomach large intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding virus receptor activity protein binding cadherin binding Cellular component integral component of membrane membrane cell-cell junction bicellular tight junction plasma membrane slit diaphragm extracellular exosome cytoplasmic vesicle cell junction Biological process regulation of actin cytoskeleton reorganization cell differentiation establishment of endothelial intestinal barrier epithelial cell differentiation actomyosin structure organization extracellular matrix organization regulation of membrane permeability regulation of cytokine production positive regulation of GTPase activity positive regulation of blood pressure cell adhesion negative regulation of GTPase activity bicellular tight junction assembly viral entry into host cell intestinal absorption response to radiation inflammatory response viral process transforming growth factor beta receptor signaling pathway leukocyte migration protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50848 16456 Ensembl ENSG00000158769 ENSMUSG00000038235 UniProt Q9Y624 O88792 RefSeq (mRNA) NM_016946 NM_144501 NM_144502 NM_144503 NM_144504 NM_001348091 NM_001382727 NM_001382730 NM_001382733 NM_001382734 NM_172647 RefSeq (protein) NP_058642 NP_001335020 NP_001369656 NP_001369659 NP_001369662 NP_001369663 NP_766235 Location (UCSC) Chr 1: 161 – 161.02 Mb Chr 1: 171.27 – 171.29 Mb PubMed search [3] [4]
Wikidata
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Function

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple transcript variants encoding two different isoforms have been found for this gene.^[7]

Interactions

F11 receptor has been shown to interact with MLLT4,^[8] CASK^[8][9] and Tight junction protein 1.^[8][10]