FABP5

Fatty acid-binding protein, epidermal is a protein that in humans is encoded by the FABP5 gene.^[5][6]

FABP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B56, 1JJJ, 4AZM, 4AZR, 4LKP, 4LKT
Identifiers
Aliases	FABP5, E-FABP, EFABP, KFABP, PA-FABP, PAFABP, fatty acid binding protein 5
External IDs	OMIM: 605168; MGI: 101790; HomoloGene: 108238; GeneCards: FABP5; OMA:FABP5 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.13 Start 81,280,536 bp[1] End 81,284,777 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A1 Start 10,077,608 bp[2] End 10,081,667 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence skin of leg skin of abdomen apex of heart subcutaneous adipose tissue mucosa of transverse colon placenta rectum vagina Top expressed in esophagus lip lens neural tube ganglionic eminence stomach ventricular zone blastocyst thymus skin More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity lipid binding protein binding fatty acid binding retinoic acid binding identical protein binding Cellular component cytoplasm nucleoplasm cytosol extracellular exosome extracellular region plasma membrane secretory granule membrane azurophil granule lumen extracellular space nucleus postsynaptic density membrane cell junction synapse postsynaptic membrane Biological process epidermis development triglyceride catabolic process phosphatidylcholine biosynthetic process glucose metabolic process lipid metabolism neutrophil degranulation transport negative regulation of glucose transmembrane transport regulation of prostaglandin biosynthetic process positive regulation of peroxisome proliferator activated receptor signaling pathway glucose homeostasis regulation of sensory perception of pain regulation of retrograde trans-synaptic signaling by endocanabinoid positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2171 16592 Ensembl ENSG00000164687 ENSMUSG00000027533 UniProt Q01469 Q05816 RefSeq (mRNA) NM_001444 NM_001272097 NM_001272098 NM_010634 RefSeq (protein) NP_001435 NP_001259026 NP_001259027 NP_034764 Location (UCSC) Chr 8: 81.28 – 81.28 Mb Chr 3: 10.08 – 10.08 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.^[6]

The phytocannabinoids (THC and CBD) inhibit endocannabinoid anandamide (AEA) uptake by targeting FABP5, and competition for FABPs may in part or wholly explain the increased circulating levels of endocannabinoids reported after consumption of cannabinoids.^[7] Results show that cannabinoids inhibit keratinocyte proliferation, and therefore support a potential role for cannabinoids in the treatment of psoriasis.^[8]

Interactions

FABP5 has been shown to interact with S100A7.^[9][10]

Inhibitors

• ART26.12