S100A7

S100 calcium-binding protein A7 (S100A7), also known as psoriasin, is a protein that in humans is encoded by the S100A7 gene.^[3]

S100A7
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1PSR, 2PSR, 2WND, 2WOR, 2WOS, 3PSR, 4AQJ
Identifiers
Aliases	S100A7, PSOR1, S100A7c, S100 calcium binding protein A7
External IDs	OMIM: 600353; HomoloGene: 48150; GeneCards: S100A7; OMA:S100A7 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,457,744 bp[1] End 153,460,651 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg testicle vagina epithelium of bronchus tonsil thymus ectocervix minor salivary glands cerebellar hemisphere n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding zinc ion binding metal ion binding protein binding RAGE receptor binding transition metal ion binding Cellular component cytoplasm cytosol focal adhesion extracellular region endoplasmic reticulum nucleus azurophil granule lumen extracellular space extracellular matrix collagen-containing extracellular matrix Biological process response to reactive oxygen species positive regulation of monocyte chemotaxis keratinocyte differentiation positive regulation of granulocyte chemotaxis sequestering of metal ion response to lipopolysaccharide positive regulation of T cell chemotaxis angiogenesis positive regulation of ERK1 and ERK2 cascade epidermis development innate immune response antimicrobial humoral response neutrophil degranulation antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6278 n/a Ensembl ENSG00000143556 n/a UniProt P31151 n/a RefSeq (mRNA) NM_002963 n/a RefSeq (protein) NP_002954 n/a Location (UCSC) Chr 1: 153.46 – 153.46 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

S100A7 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein functions as a prominent antimicrobial peptide mainly against E. coli.^[4]

S100A7 also displays antimicrobial properties. It is secreted by epithelial cells of the skin and is a key antimicrobial protein against Escherichia coli by disrupting their cell membranes. This is the reason that in countries with poor sanitation, human skin is exposed to E. coli strains from faecal matter but it does not usually result in an infection.^[5]

S100A7 is highly homologous to S100A7A (koebnerisin) but distinct in expression, tissue distribution and function.^[6][7][8][9]

Clinical significance

This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility.^[4] The expression of psoriasin is induced in skin wounds^[10] through activation of the epidermal growth factor receptor.

Interactions

S100A7 has been shown to interact with COP9 constitutive photomorphogenic homolog subunit 5,^[11] FABP5^[12][13] and RANBP9.^[14]

S100A7 interacts with RAGE (receptor of advanced glycated end products).^[6][15]