FAM151A

Family with sequence similarity 151 member A (abbreviated FAM151A) is a protein that in humans is encoded by the FAM151A gene. The protein is a transmembrane protein expressed in the kidney tubules, and is an ortholog of menorin, a protein involved in neuron development in nematodes.^[5][6]

FAM151A
Identifiers
Aliases	FAM151A, C1orf179, family with sequence similarity 151 member A
External IDs	MGI: 2657115; HomoloGene: 17143; GeneCards: FAM151A; OMA:FAM151A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band n/a Start 54,609,181 bp[1] End 54,623,556 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C7 Start 106,591,086 bp[2] End 106,605,489 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver renal cortex human kidney testicle mucosa of transverse colon apex of heart left ventricle gonad lymph node rectum Top expressed in right kidney islet of Langerhans primary oocyte human kidney proximal tubule morula morula blastocyst secondary oocyte intestinal villus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component membrane integral component of membrane extracellular exosome Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338094 230579 Ensembl ENSG00000162391 ENSMUSG00000034871 UniProt Q8WW52 Q8QZW3 RefSeq (mRNA) NM_176782 NM_146149 RefSeq (protein) NP_788954 NP_666261 Location (UCSC) Chr 1: 54.61 – 54.62 Mb Chr 4: 106.59 – 106.61 Mb PubMed search [3] [4]
Wikidata
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Gene

Genomic region of 3' UTR of gene FAM151A

The FAM151A gene contains 8 exons and is located on the minus strand of chromosome 1 at 1p32.3, spanning approximately 14 kbp.^[7][8] The last exon contains approximately half of the coding sequence, and overlaps with the 3' UTR of gene ACOT11.^[9] No alternative splicings of FAM151A are known.

Expression

FAM151A Expression in HPA RNA-seq normal tissues^[9]

Antibody staining of FAM151A in human kidney tissue

The mRNA transcript of FAM151A is expressed in the kidney, small intestine, and liver, while the FAM151A protein is only expressed in kidney tubules.^[10]

Protein

FAM151A tertiary structure as predicted by AlphaFold2

The FAM151A protein contains three known domains, one transmembrane domain and two domains of unknown function DUF2181.^[11] DUF2181 is a member of the GDPD/PLCD superfamily, which are known to hydrolyze glycerophosphodiester bonds.^[12] The second DUF2181 of FAM151A is hypothesized to be nonfunctional through homology analysis. The molecular weight of FAM151A is known to be approximately 95 kDa.^[13]

Evolutionary history

Shannon information content of amino acid residues for 20 aligned FAM151A sequences.

Orthologs of FAM151A

FAM151A has direct orthologs in chimpanzee,^[14] mouse,^[15] zebrafish,^[16] and other members of the clade Eumetazoa that diverged from humans up to around 700 million years ago.^[17][18] However, FAM151A does not have any known orthologs in birds.

Protein family FAM151/Menorin

FAM151A has one known paralog in humans, FAM151B, which contains only the first DUF2181 and no transmembrane region.^[19] In mammals, both FAM151A and FAM151B are homologs of the C. elegans menorin gene, involved in dendrite branching.^[12][6]

Clinical significance

FAM151A contains an SNP, rs11206394, that is a significant predictor of colorectal cancer. The SNP is a missense mutation that occurs in the region of the second DUF2181 of FAM151A that overlaps with the 3' UTR of ACOT11. Individuals with both copies of the minor allele have been observed to have the odds of cancer decreased between 11% and 59%.^[20]