FBXO32

F-box only protein 32, also known as "MAFbx", for "Muscle Atrophy F-box gene", and "Atrogin-1," is a protein that in humans is encoded by the FBXO32 gene.^[5][6][7]

FBXO32
Identifiers
Aliases	FBXO32, Fbx32, MAFbx, F-box protein 32
External IDs	OMIM: 606604; MGI: 1914981; HomoloGene: 12182; GeneCards: FBXO32; OMA:FBXO32 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.13 Start 123,497,889 bp[1] End 123,541,206 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D1 Start 58,039,275 bp[2] End 58,078,328 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium deltoid muscle tibialis anterior muscle myocardium of left ventricle gastrocnemius muscle quadriceps femoris muscle vastus lateralis muscle gastric mucosa biceps brachii Skeletal muscle tissue of biceps brachii Top expressed in muscle of thigh skeletal muscle tissue quadriceps femoris muscle esophagus urinary bladder uterus zone of skin heart lip cochlea More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity Cellular component cytoplasm Z discdkac nucleoplasm cytosol nucleus SCF ubiquitin ligase complex Biological process response to denervation involved in regulation of muscle adaptation cellular response to dexamethasone stimulus protein polyubiquitination protein ubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114907 67731 Ensembl ENSG00000156804 ENSMUSG00000022358 UniProt Q969P5 Q9CPU7 RefSeq (mRNA) NM_148177 NM_001242463 NM_058229 NM_026346 RefSeq (protein) NP_001229392 NP_478136 NP_680482 NP_080622 Location (UCSC) Chr 8: 123.5 – 123.54 Mb Chr 15: 58.04 – 58.08 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes.^[7]

Interactions

FBXO32 has been shown to interact with EIF3A.^[8]

Cancer

FBXO32 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[9] For this reason, FBXO32 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[9]