FBXO5

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.^[5][6][7]

FBXO5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M6N, 4UI9
Identifiers
Aliases	FBXO5, EMI1, FBX5, Fbxo31, F-box protein 5
External IDs	OMIM: 606013; MGI: 1914391; HomoloGene: 8135; GeneCards: FBXO5; OMA:FBXO5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.2 Start 152,970,519 bp[1] End 152,983,579 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 5,749,160 bp[2] End 5,755,600 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence secondary oocyte gonad bone marrow buccal mucosa cell cartilage tissue bone marrow cell trabecular bone testicle Top expressed in hand superior cervical ganglion maxillary prominence mandibular prominence primitive streak genital tubercle abdominal wall epiblast medial ganglionic eminence zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding protein kinase binding ubiquitin ligase inhibitor activity anaphase-promoting complex binding Cellular component cytoplasm cytosol spindle nucleoplasm cytoskeleton nucleus meiotic spindle Biological process vesicle organization regulation of meiotic nuclear division microtubule polymerization negative regulation of meiotic nuclear division regulation of transcription involved in G1/S transition of mitotic cell cycle cell division spindle assembly oocyte maturation regulation of mitotic cell cycle cell cycle spindle assembly involved in female meiosis I regulation of mitotic nuclear division negative regulation of ubiquitin protein ligase activity anaphase-promoting complex-dependent catabolic process negative regulation of mitotic metaphase/anaphase transition regulation of DNA replication positive regulation of cell population proliferation positive regulation of G2/M transition of mitotic cell cycle negative regulation of DNA endoreduplication positive regulation of osteoblast differentiation negative regulation of ubiquitin-protein transferase activity positive regulation of biomineral tissue development positive regulation of mesenchymal stem cell migration negative regulation of cellular senescence negative regulation of response to DNA damage stimulus protein ubiquitination regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26271 67141 Ensembl ENSG00000112029 ENSMUSG00000019773 UniProt Q9UKT4 Q7TSG3 RefSeq (mRNA) NM_001142522 NM_012177 NM_025995 RefSeq (protein) NP_001135994 NP_036309 NP_080271 Location (UCSC) Chr 6: 152.97 – 152.98 Mb Chr 10: 5.75 – 5.76 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.^[7] Moreover, Emi1 also assembles a CRL1 complex that targets RAD51 for ubiquitin-mediated degradation.^[8]

Disease

Gene and protein expression of FBXO5/Emi1 are increased in many human cancers and increased expression has been shown to cause chromosome instability and cancer.^[9]

Interactions

FBXO5 has been shown to interact with:

• CDC20,^[10]
• FZR1,^[10]
• SKP1A.^[11] and
• RAD51.^[8]