FZR1

Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene.^[5][6][7][8]

FZR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UI9
Identifiers
Aliases	FZR1, CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, fizzy/cell division cycle 20 related 1, fizzy and cell division cycle 20 related 1
External IDs	OMIM: 603619; MGI: 1926790; HomoloGene: 9444; GeneCards: FZR1; OMA:FZR1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,506,311 bp[1] End 3,538,334 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 81,202,056 bp[2] End 81,214,350 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone left testis right testis sural nerve anterior pituitary ganglionic eminence skin of leg right hemisphere of cerebellum tendon of biceps brachii stromal cell of endometrium Top expressed in spermatid seminiferous tubule ventricular zone spermatocyte interventricular septum yolk sac fetal liver hematopoietic progenitor cell dentate gyrus of hippocampal formation granule cell neural tube primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding anaphase-promoting complex binding ubiquitin-protein transferase activator activity Cellular component cytoplasm cytosol nuclear membrane nucleoplasm anaphase-promoting complex nucleus Biological process positive regulation of protein catabolic process regulation of meiotic nuclear division cellular response to DNA damage stimulus cell division protein K11-linked ubiquitination lens fiber cell differentiation protein ubiquitination positive regulation of cell population proliferation cell cycle anaphase-promoting complex-dependent catabolic process DNA repair positive regulation of ubiquitin protein ligase activity mitotic G2 DNA damage checkpoint signaling regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51343 56371 Ensembl ENSG00000105325 ENSMUSG00000020235 UniProt Q9UM11 Q9R1K5 RefSeq (mRNA) NM_001136197 NM_001136198 NM_016263 NM_019757 RefSeq (protein) NP_001129669 NP_001129670 NP_057347 NP_062731 Location (UCSC) Chr 19: 3.51 – 3.54 Mb Chr 10: 81.2 – 81.21 Mb PubMed search [3] [4]
Wikidata
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Interactions

FZR1 has been shown to interact with CDC27^[9][10] and FBXO5.^[11]