FCER1A

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene.^[5]

FCER1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F2Q, 1F6A, 1J86, 1J87, 1J88, 1J89, 1RPQ, 2Y7Q
Identifiers
Aliases	FCER1A, FCE1A, FcERI, Fc fragment of IgE receptor Ia
External IDs	OMIM: 147140; MGI: 95494; HomoloGene: 1516; GeneCards: FCER1A; OMA:FCER1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.2 Start 159,289,714 bp[1] End 159,308,224 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 80.33 cM Start 173,048,851 bp[2] End 173,054,781 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of hip skin of arm granulocyte mononuclear cell monocyte oral cavity vulva testicle gallbladder Top expressed in granulocyte tunica adventitia of aorta blood lip bone marrow skin of external ear esophagus muscle of thigh spermatid carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function IgE binding Cellular component integral component of membrane membrane plasma membrane cell surface integral component of plasma membrane Biological process Fc-epsilon receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2205 14125 Ensembl ENSG00000179639 ENSMUSG00000005339 UniProt P12319 P20489 RefSeq (mRNA) NM_002001 NM_010184 RefSeq (protein) NP_001992 NP_034314 Location (UCSC) Chr 1: 159.29 – 159.31 Mb Chr 1: 173.05 – 173.05 Mb PubMed search [3] [4]
Wikidata
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Function

The high affinity IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes—potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha (this protein), beta, and gamma; only the alpha subunit is glycosylated.^[6]