MS4A2

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.^[5][6]

MS4A2
Identifiers
Aliases	MS4A2, APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1, membrane spanning 4-domains A2
External IDs	OMIM: 147138; MGI: 95495; HomoloGene: 112; GeneCards: MS4A2; OMA:MS4A2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 60,088,261 bp[1] End 60,098,467 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 8.46 cM Start 11,592,887 bp[2] End 11,601,083 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad gallbladder testicle rectum monocyte right coronary artery gastric mucosa smooth muscle tissue upper lobe of left lung skin of hip Top expressed in renal corpuscle skin of external ear granulocyte dermis otic vesicle embryo blood epithelium of stomach lip bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function IgE binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane external side of plasma membrane Fc-epsilon receptor I complex Biological process Fc-epsilon receptor signaling pathway cell surface receptor signaling pathway inflammatory response immune response signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2206 14126 Ensembl ENSG00000149534 ENSMUSG00000024680 UniProt Q01362 P20490 RefSeq (mRNA) NM_000139 NM_001142303 NM_001256916 NM_001276328 NM_001276329 NM_001276330 NM_013516 RefSeq (protein) NP_000130 NP_001243845 NP_001263257 NP_001263258 NP_001263259 NP_038544 Location (UCSC) Chr 11: 60.09 – 60.1 Mb Chr 19: 11.59 – 11.6 Mb PubMed search [3] [4]
Wikidata
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Function

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.^[6]

See also

• FcεRI