FEZF1

FEZ family zinc finger 1 is a protein that in humans is encoded by the FEZF1 gene.^[5]

FEZF1
Identifiers
Aliases	FEZF1, FEZ, ZNF312B, HH22, FEZ family zinc finger 1
External IDs	OMIM: 613301; MGI: 1920441; HomoloGene: 19252; GeneCards: FEZF1; OMA:FEZF1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.32 Start 122,301,303 bp[1] End 122,310,691 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.1 Start 23,245,043 bp[2] End 23,248,361 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle hypothalamus caudate nucleus amygdala olfactory zone of nasal mucosa putamen left testis nucleus accumbens gonad right testis Top expressed in external naris ventromedial nucleus respiratory epithelium olfactory epithelium Jacobson's organ lumbar spinal ganglion zygote suprachiasmatic nucleus mesencephalon lateral hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding nucleic acid binding DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus cytosol Biological process forebrain anterior/posterior pattern specification cell differentiation regulation of transcription, DNA-templated neuron migration negative regulation of transcription by RNA polymerase II transcription, DNA-templated nervous system development positive regulation of transcription, DNA-templated multicellular organism development telencephalon development positive regulation of neuron differentiation forebrain development olfactory bulb development negative regulation of cell population proliferation axon guidance cell dedifferentiation regulation of neurogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 389549 73191 Ensembl ENSG00000128610 ENSMUSG00000029697 UniProt A0PJY2 Q0VDQ9 RefSeq (mRNA) NM_001024613 NM_001160264 NM_028462 RefSeq (protein) NP_001019784 NP_001153736 NP_082738 Location (UCSC) Chr 7: 122.3 – 122.31 Mb Chr 6: 23.25 – 23.25 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

FEZF1 is a gene that encodes for transcriptional repressors, and it has been shown to repress the transcription factor HES5.^[6] In the mouse, FEZF1 is expressed in the forebrain in early development of the embryo. This suppression of HES5 helps to control the differentiation of neural stem cells.^[6] FEZF1 also helps to divide the caudal forebrain into three distinct parts during development: the prethalamus, the thalamus, and the pretectum. Mice lacking FEZF1 had no prethalamus and had a smaller thalamus.^[7] A loss of function mutation in FEZF1 causes Kallmann Syndrome.^[8] As axons are developing and migrating in the early embryo, FEZF1 allows the axons of olfactory neurons to attach to the central nervous system in the mice model. During neural development, GnRH neurons migrate through one of these olfactory axon pathways, and the loss of function of FEZF1 therefore results in the loss of GnRH neurons in the brain, the hallmark of Kallmann Syndrome.^[8]