FHL3

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.^[5][6][7]

FHL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WYH, 2CUQ, 2EHE
Identifiers
Aliases	FHL3, SLIM2, four and a half LIM domains 3
External IDs	OMIM: 602790; MGI: 1341092; HomoloGene: 37928; GeneCards: FHL3; OMA:FHL3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 37,996,770 bp[1] End 38,005,606 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 124,594,494 bp[2] End 124,602,404 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle Skeletal muscle tissue of rectus abdominis vastus lateralis muscle Skeletal muscle tissue of biceps brachii thoracic diaphragm triceps brachii muscle deltoid muscle tibialis anterior muscle body of uterus Top expressed in muscle of thigh lip granulocyte esophagus genital tubercle yolk sac urethra skeletal muscle tissue embryo male urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding metal ion binding Cellular component Z discdkac nucleus stress fiber focal adhesion Biological process muscle organ development actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2275 14201 Ensembl ENSG00000183386 ENSMUSG00000032643 UniProt Q13643 Q96C98 Q9R059 RefSeq (mRNA) NM_004468 NM_001243878 NM_010213 RefSeq (protein) NP_001230807 NP_004459 NP_001230807.1 NP_034343 Location (UCSC) Chr 1: 38 – 38.01 Mb Chr 4: 124.59 – 124.6 Mb PubMed search [3] [4]
Wikidata
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LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.^[7]

Function

FHL3 plays a role in myogenesis,^[8] and also stimulates the development of neural crest by enhancing BMP signaling.^[9]

Interactions

FHL3 has been shown to interact with:

• CREB1,^[10]
• CTBP2,^[11]
• FHL2,^[10][12]
• ITGA7^[13] and
• KLF3.^[11]