FHL5

Four and a half LIM domains protein 5 is a protein that in humans is encoded by the FHL5 gene.^[5]

FHL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X68
Identifiers
Aliases	FHL5, ACT, dJ393D12.2, 1700027G07Rik, FHL-5, four and a half LIM domains 5
External IDs	OMIM: 605126; MGI: 1913192; HomoloGene: 23230; GeneCards: FHL5; OMA:FHL5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q16.1 Start 96,562,548 bp[1] End 96,618,626 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A3 Start 25,199,908 bp[2] End 25,242,876 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries right coronary artery sperm left coronary artery right testis left testis pericardium Achilles tendon Descending thoracic aorta Top expressed in seminiferous tubule spermatid spermatocyte male urethra muscle of thigh secondary oocyte esophagus zygote primary oocyte skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein binding metal ion binding Cellular component nucleus Z discdkac Biological process positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9457 57756 Ensembl ENSG00000112214 ENSMUSG00000028259 UniProt Q5TD97 Q9WTX7 RefSeq (mRNA) NM_001170807 NM_020482 NM_001322466 NM_001322467 NM_021318 NM_001355498 NM_001379528 RefSeq (protein) NP_001164278 NP_001309395 NP_001309396 NP_065228 NP_067293 NP_001342427 NP_001366457 Location (UCSC) Chr 6: 96.56 – 96.62 Mb Chr 4: 25.2 – 25.24 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene.^[5]

Interactions

FHL5 has been shown to interact with CREB1^[6] and CAMP responsive element modulator.^[6][7]