FLII

This article is about the protein. For the environmental index, see Forest Landscape Integrity Index.

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.^[5][6]

FLII
Identifiers
Aliases	FLII, FLI, FLIL, Fli1, actin remodeling protein, FLII actin remodeling protein
External IDs	OMIM: 600362; MGI: 1342286; HomoloGene: 11092; GeneCards: FLII; OMA:FLII - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p11.2 Start 18,244,815 bp[1] End 18,258,738 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B2|11 37.81 cM Start 60,604,949 bp[2] End 60,618,089 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh gastrocnemius muscle skeletal muscle tissue spleen mucosa of transverse colon pituitary gland anterior pituitary minor salivary glands right lobe of thyroid gland Top expressed in Ileal epithelium choroid plexus of fourth ventricle granulocyte cardiac muscle tissue of left ventricle lactiferous gland tracheobronchial tree internal carotid artery mesenteric lymph nodes right lung lobe muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding actin filament binding Cellular component cell junction cytoskeleton brush border nucleus focal adhesion nucleoplasm microtubule organizing center cytoplasm cytosol Biological process multicellular organism development actin filament severing regulation of transcription, DNA-templated actin cytoskeleton organization transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2314 14248 Ensembl ENSG00000177731 ENSG00000284571 ENSMUSG00000002812 UniProt Q13045 Q9JJ28 RefSeq (mRNA) NM_001256264 NM_001256265 NM_002018 NM_022009 NM_001302207 RefSeq (protein) NP_001243193 NP_001243194 NP_002009 NP_001289136 NP_071292 Location (UCSC) Chr 17: 18.24 – 18.26 Mb Chr 11: 60.6 – 60.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.^[7] The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.^[6]

Interactions

FLII has been shown to interact with LRRFIP1^[8][9] and TRAF interacting protein.^[10]