LRRFIP1

Leucine-rich repeat flightless-interacting protein 1 is a protein that in humans is encoded by the LRRFIP1 gene.^[5][6][7][8]

LRRFIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H22
Identifiers
Aliases	LRRFIP1, FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP, leucine rich repeat (in FLII) interacting protein 1, LRR binding FLII interacting protein 1
External IDs	OMIM: 603256; MGI: 1342770; HomoloGene: 48301; GeneCards: LRRFIP1; OMA:LRRFIP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 237,627,587 bp[1] End 237,813,682 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 90,998,737 bp[2] End 91,128,944 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla endothelial cell cardia nipple pylorus visceral pleura superior surface of tongue buccal mucosa cell mucosa of pharynx pericardium Top expressed in secondary oocyte zygote endothelial cell of lymphatic vessel conjunctival fornix granulocyte primary oocyte urothelium hair follicle transitional epithelium of urinary bladder lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding double-stranded RNA binding protein binding protein homodimerization activity cadherin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component plasma membrane cytoskeleton nucleus cytoplasm cytosol Biological process regulation of transcription by RNA polymerase II negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of type I interferon production transcription, DNA-templated negative regulation of transcription by RNA polymerase II positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9208 16978 Ensembl ENSG00000124831 ENSMUSG00000026305 UniProt Q32MZ4 Q3UZ39 RefSeq (mRNA) NM_001137550 NM_001137551 NM_001137552 NM_001137553 NM_004735 NM_001111311 NM_001111312 NM_008515 NM_001310732 RefSeq (protein) NP_001131022 NP_001131023 NP_001131024 NP_001131025 NP_004726 NP_001104781 NP_001104782 NP_001297661 NP_032541 Location (UCSC) Chr 2: 237.63 – 237.81 Mb Chr 1: 91 – 91.13 Mb PubMed search [3] [4]
Wikidata
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Interactions

LRRFIP1 has been shown to interact with FLII.^[6][9]